Journal: Antimicrobial Agents and Chemotherapy
Article Title: Spheroplast-Mediated Carbapenem Tolerance in Gram-Negative Pathogens
doi: 10.1128/AAC.00756-19
Figure Lengend Snippet: Bacterial isolates evaluated in this study a
Article Snippet: Our results suggest that measurement of antibiotic susceptibility and, ultimately, treatment outcome could include more-nuanced responses, such as tolerance, in Gram-negative pathogens. table ft1 table-wrap mode="anchored" t5 TABLE 1 caption a7 Isolate Carbapenemase Specimen source MHA MIC value (μg/ml) MHA MIC value interpretation e BHI + agar MIC value (μg/ml) BHI + agar MIC value interpretation f E. cloacae complex ARB0008 b NA NA 1 SUS 1.5 NA E. cloacae complex ATCC 13047 NA NA 0.064 SUS 0.094 NA E. cloacae complex WCM0001 NA Blood 0.023 SUS 0.023 NA E. coli WCM0001 NA Urine 0.016 SUS 0.016 NA E. coli TUV93-0 NA NA 0.023 SUS 0.023 NA K. aerogenes ARB0007 NA NA 0.064 SUS 0.047 NA K. aerogenes WCM0001 NA Respiratory/sinus 0.032 SUS 0.032 NA K. pneumoniae WCM0001 NA Blood 0.047 SUS 0.032 NA K. pneumoniae WCM0002 NA Respiratory/sinus 0.032 SUS 0.064 NA P. aeruginosa PA14 NA NA 0.25 SUS 0.25 NA V. cholerae N16961 NA NA 0.125 SUS 0.125 NA E. cloacae complex 41952 KPC NA >32 RES >32 NA E. coli 52862 KPC NA >32 RES 32 NA K. aerogenes 28944 KPC NA >32 RES >32 NA K. pneumoniae ARB0120 c KPC NA 16 RES 16 NA P. aeruginosa ARB0090 d KPC NA >32 RES >32 NA Open in a separate window a ARB, Centers for Disease Control and Prevention and U.S. Food and Drug Administration Antibiotic Resistance Isolate Bank; ATCC, American Type Culture Collection; BHI + , brain heart infusion agar with supplements; MHA, Mueller-Hinton agar; NA, not applicable; RES, resistant; SUS, susceptible; WCM, Weill Cornell Medicine. b For ARB0008, the meropenem MIC value determined by the ARB is 2 μg/ml (intermediate).
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